Funding for this research was provided by:
Sosiaali- ja Terveysministeriö (VTR September 15, 2016)
Social insurance institution of Finland (94/331/2013)
South Karelia social and health care district (1236/00.01.05.01/2013)
Text and Data Mining valid from 2018-10-01
Received: 10 July 2017
Accepted: 12 September 2018
First Online: 1 October 2018
Ethics approval and consent to participate
: The HIPFRA study has been evaluated in the Helsinki University Hospital’s (HUS) Coordinating Ethics Committee. The study protocol was approved by the coordinating ethics committee on Nov 14, 2014 (document identification number 253/13/03/00/14). Some minor amendment to the research protocol of HIPFRA study documents was made in spring 2017, and approved by the HUS Coordinating Ethics Committee on March 21, 2017 (HUS/891/2017).This study will comply with the Declaration of Helsinki and the Finnish legislation on Medical research act (488/1999, changed 295/2004, 794/2010, 143/2015). All participants are given both oral and written information about the study and they sign an informed consent before randomization.
: Not applicable.
: The authors declare that they have no competing interests.
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