Funding for this research was provided by:
National Natural Science Foundation of China (81973139, 81470498, 81202778, 81670432)
Natural Science Foundation of Shandong Province (ZR2016HM82)
Key Technology Research and Development Program of Shandong (2019GSF108079, 2011GSF11822, 2018GSF118044, 2017GSF218060)
Innovation Project of Shandong Academy of Medical Sciences (NA)
Received: 2 August 2019
Accepted: 29 July 2020
First Online: 17 August 2020
Ethics approval and consent to participate
: Ethical approval was obtained from the Research Ethics Committee of the Institute of Basic Medicine, Shandong Academy of Medical Sciences (registration number: 2008-03-06 for the cohort study and 2007-12-09 for the clinical trial). Trial registry: ChiCTR-EOC-017013598 and ChiCTR-IOR-17013557. Each participant provided written informed consent.
: Not applicable.
: The authors have no financial conflicts of interest.