Funding for this research was provided by:
Deutsche Forschungsgemeinschaft (323965454)
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (100019E-170410)
Received: 9 February 2020
Accepted: 8 September 2020
First Online: 21 October 2020
Ethics approval and consent to participate
: In Geneva, the full protocol including MRI was approved by the Commission cantonale d’éthique de la recherche de Genève (CCER; no. 2016–02224) on 22.05.2017 (protocol version 3), amendment no. 1 on 27.02.2018 (additional blood sampling; protocol version 4) and amendment no. 2 on 21.01.2020 (increased number of participants, completed measurements, information on data storage, up to date Timelines; protocol version 5). Protocol versions 4 & 5 conserved the CCER number 2016–02224.In Hannover, the Ethikkomission of the Leibniz Universität Hannover (LUH) approved the whole protocol on 14.08.2017 (no. 3604–2017), the Hannover Medical School consecutively approved the MRI part separately on 29.08.2017 and additional blood sampling as an amendment on 07.03.2018, conserving the LUH number (3604–2017).Retrospectively registered on 17.09.2018 (ExternalRef removed Identifier: ExternalRef removed, study no. 81185), some participants were already enrolled.
: All participants signed a declaration of informed consent to participate in the study and accepted by their signature that the obtained data could be used for publication, under the condition that data will remain anonymous (see Table InternalRef removed).
: The authors declare that there are no competing interests.