Funding for this research was provided by:
the Mega Projects of National Science Research for the 12th Five-Year Plan (2014ZX10001002001004)
the Platform project for close combination of Basic and clinical medicine (YIDA FAZI  no.5)
Received: 6 December 2016
Accepted: 7 February 2018
First Online: 13 February 2018
Ethics approval and consent to participate
: The Medical Science Research Ethics Committee of the First Affiliated Hospital of China Medical University (Shenyang, China) approved the study protocol (KELUNSHEN  number 36). Our study was conducted according to the principles enshrined in the Declaration of Helsinki. Written informed consent to take part in the study was obtained from all participants.
: Not applicable.
: The authors declare that they have no competing interests.
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