Funding for this research was provided by:
UNITAID & The Global Fund (2018-25 Catalytic LLIN)
Received: 18 January 2021
Accepted: 9 February 2021
First Online: 19 February 2021
Ethics approval and consent to participate
: This study is to be conducted following the principles outlined in the ICH Harmonized Tripartite Guideline for Good Clinical Practice and the Declaration of Helsinki. The Benin Ministry of Health ethics committee (Reference N°6/30/MS/DC/SGM/DRFMT/CNERS/SA) approved this study. It is also approved by the institutional review board of the London School of Hygiene and Tropical Medicine (Reference N°16237) and the WHO Research Ethics Review Committee (Reference ERC.0003153).Before any project activities, villages and hamlet leaders and local health staff will be invited to sensitisation sessions. Community health workers within each cluster will be fully informed as to the aims of the trial and will be on hand to answer day to day questions regarding the study. For all activities involving a household, written informed consent will be obtained from an adult guardian in the household or be given by the participant if over 18 years. All participation is completely voluntary, and participants can withdraw at any time. In case the participant does not understand French, study investigators will be trained to practice oral translation of the consent into local languages. Participants will be asked to sign the consent in duplicate, one will be kept by the project and the other will remain with the household. If the person consenting is unable to read or write, their fingerprint will be taken, and an impartial witness to the informed consent procedures signature will be requested to sign. For the active follow-up cohort, consent will be sought once at the first enrolment visit and will be performed by the study nurses. Assent will be sought for children over 10 years.For HLCs, written informed consent will also be obtained from volunteer mosquito collectors before being involved in the study. Mosquito collectors will be over the age of 18 years. To prevent yellow fever, they will be vaccinated. Their health will be monitored by the project clinical team and free treatment for malaria will be provided, if necessary. Each volunteers will work one night every 3 months to reduce the risk.
: Not applicable.
: The authors declare that they have no competing interests.