Funding for this research was provided by:
the Natural Science Foundation of China (81170653)
the Shandong Provincial Natural Science Foundation (ZR2014JL054)
Received: 11 April 2018
Accepted: 12 September 2018
First Online: 20 September 2018
Ethics approval and consent to participate
: The study was approved by the Ethics Committee of the Affiliated Hospital of Qingdao University, and the methods were carried out in accordance with the approved guidelines. Written informed consent to participate was obtained for all participants(including all family members of this pedigree and 100 unrelated controls)before collecting blood samples.
: Written informed consent for the publication of this case report, any accompanying medical data and gene detection results was obtained from all participants or from the guardians of participants < 18 years old. A copy of the written consent is available for review by the journal editor. All authors have approved the publication of this manuscript.
: The authors declare that they have no competing interests.
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