Funding for this research was provided by:
National Natural Science Foundation of China (grants 81570884, 81770961)
the SMC-ChenXing Yong Scholar Program (2016, Class A)
the Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant (20152223)
Innovation Fund for Translational Medicine (15ZH1005)
Ph.D. Programs Foundation of Shanghai JiaoTong University School of Medicine (BXJ201834)
Received: 10 March 2019
Accepted: 18 August 2019
First Online: 18 September 2019
Ethics approval and consent to participate
: Ethics approval for this study was obtained from Shanghai Jiaotong University. For all samples, only non-identifiable information is presented. Written, informed consent was obtained for all involved patients. Informed consent was obtained from all patients or their guardians at the follow-up visit.
: Written, informed consent was obtained for all involved patients. A form letter containing the carrier screening agreement for children younger than 18 years old was signed by their parents.
: The authors declare that they have no competing interests.