Funding for this research was provided by:
Higher Education Commision, Pakistan (1-8/HEC/HRD/2017/17326, PIN: IRSIP 35 BMS 26)
Danish Innovation Foundation (NNF15CC0018486)
Novo Nordisk Fonden (NNF18CC0034900)
Received: 18 March 2019
Accepted: 29 August 2019
First Online: 5 September 2019
Ethics approval and consent to participate
: The current study protocol was conducted in accordance with the guidelines of the Helsinki Declaration. Informed consent forms were obtained from individuals aged 18 years or older, while informed consent for individuals < 18 years of age was obtained from their parents or guardians. The current study protocol was approved by the local Ethical Committee with the name of ‘Ethics Review Board (ERB) of Pakistan Institute of Medical Sciences (PIMS) at Shaheed Zulfiqar Ali Bhutto Medical University (SZABMU), Islamabad, Pakistan and the committee’s reference number is No. F. 1–1/2015/ERB/SZABMU/−.
: Written informed consent was obtained from the patients or their parents for the publication of their clinical data and genetic data.
: The authors declare that no conflicts interests.