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Article History

Received: 12 December 2018

Accepted: 22 May 2019

First Online: 8 June 2019

Ethics approval and consent to participate

: The study was approved by the ethics committee of the Charité – Universitätsmedizin Berlin (EA1/025/11). All patients gave written informed consent in accordance with the Declaration of Helsinki in its currently applicable form. This consent was signed by the patient if possible, or by a third person in the presence of the full conscientious patient. These criteria were approved by the ethics committee. Any patient in this study was able to provide written informed consent due their condition.

: Not applicable.

: J Klehmet received speaker’s honoraria and travels grants from Grifols, Octapharma, CSL Behring, Novartis, Bayer and Merck. S Beutner, S Hoffmann, M Dornauer, and A Meisel declare no competing interests. F Paul serves on the scientific advisory board for Novartis; received speaker honoraria and travel funding from Bayer, Novartis, Biogen Idec, Teva, Sanofi-Aventis/Genzyme, Merck Serono, Alexion, Chugai, MedImmune, and Shire; is an academic editor for <i>PLoS ONE</i>; is an associate editor for <i>Neurology</i>® <i>Neuroimmunology & Neuroinflammation</i>; consulted for SanofiGenzyme, Biogen Idec, MedImmune, Shire, and Alexion; and received research support from Bayer, Novartis, Biogen Idec, Teva, Sanofi-Aventis/Genzyme, Alexion, Merck Serono, German Research Council, Werth Stiftung of the City of Cologne, German Ministry of Education and Research, Arthur Arnstein Stiftung Berlin, EU FP7 Framework Program, Arthur Arnstein Foundation Berlin, Guthy Jackson Charitable Foundation, and National Multiple Sclerosis of the USA. R Reilmann is founding director and owner of the George-Huntington-Institute, a private research institute focused on clinical and preclinical research in Huntington’s disease, and QuantiMedis, a clinical research organization providing Q-Motor (quantitative motor) services in clinical trials and research. He holds appointments at the Dept. of Radiology of the University of Muenster and at the Department of Neurodegenerative Diseases and Hertie-Institute for Clinical Brain Research, University of Tuebingen. Dr. Reilmann serves as elected member of the Steering Committees of the European Huntington Disease Network (EHDN) and the Huntington Study Group (HSG), co-chair of the Task Force on Huntington’s disease and member of the Task Force on Technology of the International Parkinson and Movement Disorder Society (IPMDS). He has provided consulting services, advisory board functions, clinical trial services, quantitative motor analyses, and/or lectures for Actelion Pharmaceuticals, Amarin Neuroscience, AOP Orphan Pharmaceuticals, Cure Huntington Disease Initiative Foundation (CHDI), Desitin, Hoffmann-La Roche, IONIS Pharmaceuticals, Ipsen, Lundbeck, Link Medicine, MEDA Pharma, Medivation, Mitoconix, Neurosearch, Novartis AG, Omeros, Pfizer, Prana Biotechnology, Prilenia, Raptor Pharmaceuticals, Siena Biotech, Temmler Pharma, Teva Pharmaceuticals, uniQure, Vaccinex, Wave Life Sciences, and Wyeth Pharmaceuticals. He has received grant support from the Bundesministerium für Bildung und Forschung (BMBF), the Cure Huntington Disease Initiative Foundation (CHDI), the Deutsche Forschungsgemeinschaft (DFG), the Deutsches Zentrum für Neurodegeneration und Entzündung (DZNE), the European Union 7th Framework Program (EU-FP7), the European Huntington Disease Network (EHDN), the High-Q-Foundation, and the National Science Foundation (NSF). A U Brandt is cofounder and shareholder of technology companies Motognosis GmbH and Nocturne GmbH. He is named as inventor on several patent applications describing serum biomarkers in multiple sclerosis, perceptive visual computing based motion analysis and retinal image analysis.