Funding for this research was provided by:
H2020 Marie Skłodowska-Curie Actions (661883)
Weston Brain Institute (NR160180, NR170062)
Received: 18 December 2019
Accepted: 28 May 2020
First Online: 13 June 2020
Ethics approval and consent to participate
: DUPARC is conducted in accordance with the Declaration of Helsinki and national and international standards of GCP. Potential participants receive detailed written and oral information on the study procedures and all participants provide written informed consent. Ethical approval of the study protocols was obtained from the Medical Ethics Review Board of the University Medical Center Groningen (METc UMCG). The DUPARC study protocol is registered at the Dutch Central Committee on Research Involving Human Subjects (CCMO) with trial registration number NL60540.042.17, whereas the microbiome study is registered separately with trial registration number NL61123.042.17. In addition, the study has been registered retrospectively on November 28th 2019 at ExternalRef removed, with identifier ExternalRef removed.
: Not applicable.
: <b>TvL</b> has received research support from the Weston Brain Institute, speaker fees from Britannia, AbbVie and Medtronic, and is on the advisory boards of LTI and Neuroderm.