Funding for this research was provided by:
Received: 8 April 2020
Accepted: 23 September 2020
First Online: 6 October 2020
Ethics approval and consent to participate
: In the multiple studies comprising this post hoc pooled analysis, the protocols were approved by central and local ethics committees and the review board at each of the multiple sites (see Supplementary Table InternalRef removed in supplementary information for details). Patients provided written informed consent before participating in the trials. All studies were carried out in accordance with the International Conference on Harmonisation Guidelines for Good Clinical Practice and the World Medical Association’s Declaration of Helsinki and its amendments.
: Not applicable.
: <b>Giancarlo Comi:</b> Compensation for consulting services and/or speaking activities (Almirall, Biogen, Celgene, Excemed, Forward Pharma, Genzyme, Merck, Novartis, Receptos, Roche, Sanofi, Teva); fees for non-CME services (Almirall, Bayer, Biogen, Excemed, Genzyme, Merck Serono, Novartis, Receptos, Sanofi, SSIF, Teva). <b>Mark S Freedman:</b> Research/educational grant support (Genzyme); honoraria/consulting fees (Actelion [J&J], Bayer HealthCare, Biogen, Chugai, EMD Canada, Genzyme, Merck, Novartis, Roche, Sanofi, Teva Canada Innovation); member of company advisory boards/board of directors/other similar group (Bayer HealthCare, Biogen, Chugai, Genzyme, Merck Serono, Novartis, Roche, Sanofi, Teva Canada Innovation). <b>José E Meca-Lallana:</b> Grants or speaking and consultation honoraria (Almirall, Biogen, Celgene, Genzyme, Merck, Novartis, Roche, Teva). <b>Patrick Vermersch:</b> Honoraria, consulting fees (Almirall, Bayer, Biogen, Celgene, Genzyme, GSK, Merck Serono, Novartis, Sanofi, Servier, Teva); research support (Bayer, Biogen, Genzyme, Merck Serono, Sanofi). <b>Byoung Joon Kim:</b> Honoraria, consulting fees (Astellas, Bayer, Celltrion, Corestem, Genuv, Genzyme). <b>Alexander Parajeles:</b> Nothing to disclose. <b>Keith R Edwards:</b> Consulting fees (EMD Serono); research support (Biogen, Genentech, Novartis, Sanofi). <b>Ralf Gold:</b> Consulting fees (Bayer Schering, Biogen, Elan, Genzyme, Roche, Teva); grant/research support (Bayer Schering, Biogen, Genzyme, Teva). <b>Houari Korideck and Elizabeth M Poole:</b> Employees of Sanofi at the time the study was conducted. <b>Jeffrey Chavin:</b> Employee of Sanofi. <b>Patricia K Coyle:</b> Consulting fees (Accordant, Biogen, Genentech/Roche, Genzyme/Sanofi, Novartis, Serono, TG Therapeutics); research support (Actelion, Alkermes, Corrona LLD, Genentech/Roche, MedDay, NINDS, Novartis).