Funding for this research was provided by:
Bundesministerium für Bildung und Forschung (No: 01GL1804)
Received: 9 July 2020
Accepted: 16 November 2020
First Online: 3 December 2020
Ethics approval and consent to participate
: The study protocol was approved by the leading ethics committee (University Leipzig, Reference 153/19-ff) and the federal authority (BfArM). The study is approved to enrol patients who are unable to provide informed consent according to paragraph 41 of the German Medicinal Products Act. Patients initially unable to provide consent must be informed about the clinical study and receive written and oral information as soon as they are able to do so and will then be asked to provide their written informed consent. If the patient has not regained consciousness 72 h after inclusion into the study, the establishment of a legal care relationship should be initiated at the responsible local court.
: Not applicable.
: HM Hamer has served on the scientific advisory board of Arvelle, Bial, Desitin, Eisai, facetoface, GW, Novartis, Sandoz and UCB Pharma. He served on the speakers’ bureau of or received unrestricted grants from Amgen, Ad-Tech, Bial, Bracco, Desitin, Eisai, GW, Nihon Kohden, Novartis, Pfizer, and UCB Pharma. F Rosenow reports grants from European Union, grants from the DFG, grants from BMBF ERAPerMed Programme, grants from LOEWE-Programme of the Federal State of Hessen, Germany, grants from Detlev-Wrobel-Fonds for Epilepsy Research, grants from the Uniscientia Foundation, personal fees from Arvelle Therapeutics, EISAI, GW Pharmaceuticals, UCB Pharma, Ludwig-Maximilian-Universität Munich and Metronics, outside the submitted work. The other authors declare that they have no competing interests.