Received: 23 October 2020
Accepted: 21 January 2021
First Online: 12 February 2021
Ethics approval and consent to participate
: This research included an unpublished study with human participants. All procedures performed in this unpublished study are in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments, and have been approved by the Oregon Health & Science University’s institutional review board.
: Not applicable.
: XL, AY, NB, and JB are employees of QualityMetric, which received funding from Akcea Therapeutics for conducting this research. MVL and DB are employees of and own stock in Akcea Therapeutics. CK has received support from Acceleron, Akcea Therapeutics, Alexion, Alnylam, Biogen, Cytokinetics, CSL Behring, and Sanofi Genzyme. BV declares no conflict of interest.