Received: 8 October 2021
Accepted: 22 November 2021
First Online: 10 December 2021
: All study protocols and procedures were performed in accordance with relevant guidelines and regulations, and were approved by the institutional review board at Massachusetts General Hospital. Written informed consent was obtained from all study participants or their surrogates.
: Not applicable.
: Ms. Sophia Keins reports no disclosures. Ms. Jessica Abramson reports no disclosures. Dr. Juan Pablo Castello reports no disclosures. Dr. Marco Pasi reports no disclosures. Dr. Andreas Charidimou reports no disclosures. Ms. Christina Kourkoulis reports no disclosures. Ms. Zora DiPucchio reports no disclosures. Ms. Kristin Schwab reports no disclosures. Dr. Christopher D. Anderson is supported by R01NS103924, U01NS069763, the AHA-Bugher Foundation, receives sponsored research support from Massachusetts General Hospital and Bayer AG, and consulting for ApoPharma and Invitae. Dr. M. Edip Gurol is supported by K23NS083711. Dr. Steven M Greenberg is supported by R01AG26484. Dr. Jonathan Rosand is supported by the AHA-Bugher Foundation, R01NS036695, UM1HG008895, R01NS093870, R24NS092983, and has consulted for New Beta Innovations, Boehringer Ingelheim, and Pfizer Inc. Dr. Anand Viswanathan is supported by R01AG047975, R01AG026484, P50AG005134. Dr. Alessandro Biffi is supported by the AHA-Bugher Foundation, Massachusetts General Hospital and K23NS100816.