Funding for this research was provided by:
Bill and Melinda Gates Foundation (OPP1107597)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (401615/2013-8)
Received: 8 April 2019
Accepted: 16 September 2019
First Online: 27 November 2019
Ethics approval and consent to participate
: The Brazilian National Review Board (CONEP) approved the study under the number 1.055.555. Each local Institutional Review Boards also approved the study protocol (a list of ethic committee is available in Additional file InternalRef removed). Protocol modifications will be reported to each relevant part including national and local institutional review boards and will be available to trial participants through the project website, to the investigators by an internal bulletin, to the registries and journals by publications, and to regulators by the review board report. A written informed consent will be obtained from study participants. In case of an eligible participant under 18 years old, a consent form will be signed for both the underaged participant and his/her legal guardian/parent before been admitted into the study.
: Not applicable.
: The authors declare that they have no competing interests.