Mehnert, Janice M.
Varga, Andrea
Brose, Marcia S.
Aggarwal, Rahul R.
Lin, Chia-Chi
Prawira, Amy
de Braud, Filippo
Tamura, Kenji
Doi, Toshihiko
Piha-Paul, Sarina A.
Gilbert, Jill
Saraf, Sanatan
Thanigaimani, Pradeep
Cheng, Jonathan D.
Keam, Bhumsuk
Funding for this research was provided by:
Merck & Co., Inc., Kenilworth, NJ, USA
Article History
Received: 22 January 2018
Accepted: 19 February 2019
First Online: 4 March 2019
Ethics approval and consent to participate
: The study protocol and all amendments were approved by the institutional review board or ethics committee of each participating site (Additional fileInternalRef removed: Table S1) and were conducted per the principles expressed in the Declaration of Helsinki. All patients provided written informed consent to participate.
: Not applicable.
: JMM: Consulting or Advisory Role: Merck, EMD Serono, Genentech. MSB: Research Funding: Merck (institution). AP: Research Funding: Merck (institution). TD: Research Funding: Taiho, Novartis, Merck Serono, Astellas Pharma, Merck, Janssen, Boehringer Ingelheim, Takeda, Pfizer, Lilly Sumitomo Group, Chugai Pharma, Bayer, Kyowa, Hakko Kirin, Daiichi Sankyo, Celgene, Amgen. SAP-P: Research Funding: AbbVie, Inc., Aminex Therapeutics, BioMarin Pharmaceutical, Inc., Bristol Myers Squib; Curis, Inc., Five Prime Therapeutics, Genmab, GlaxoSmithKline, Helix BioPharma Corp., Incyte Corp., Medivation, Inc., Merck Sharp and Dohme Corp., Novartis Pharmaceuticals, Pieris Pharmaceuticals, Inc., Pfizer, Puma Biotechnology, Inc., Taiho Oncology, Tesaro, Inc., TransThera Bio, XuanZhu Pharma Co, Ltd., Principia Biopharma, Inc., Cerulean Pharma, Inc., Medimmune, LLC, Boehringer Ingelheim, Jacobio Pharmaceuticals Co, Ltd. SS: Employment: Merck Sharp & Dohme Corp., a subsidiary of Merck and Co., Inc. PT: Employment (at the time of analysis): Merck Sharp & Dohme Corp., a subsidiary of Merck and Co., Inc.; Current employment: Regeneron; Stockholder: MannKind Corporation and Regeneron. JC: Employment: Merck Sharp & Dohme Corp., a subsidiary of Merck and Co., Inc. The other authors declare that they have no competing interests.
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