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Article History

Received: 24 September 2018

Accepted: 26 February 2019

First Online: 4 March 2019

Ethics approval

: All work with animals was conducted in accordance with the local Committee of Ethics on animal experimentation guidelines for the humane treatment of animals and complies with the legislation of the Republic of Lithuania. The ethical approvals from Vilnius Regional Bioethics Committee relevant to the presented study: No. G2–22 (issued on 01/13/2015) and No. G2–66 (issued on 05/26/2017). The author A.D. had a certificate (No. 303, issue date: 2015-09-04) to work with laboratory animals issued by Lithuanian Natural Sciences faculty department of biomodels. Copies of the certificate and ethics approvals can be provided upon a request. Human tissue samples and personal data were not used in this study. None of the commercial cell lines used in this study required ethics approval.

: Not applicable

: J.U. and R.M. declare potential financial interests in the future development and commercialization of the Vcz deaminase. Vilnius University has filed a Lithuanian patent application (LT2017533). Other authors declare that they have no competing interests.

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