Funding for this research was provided by:
Fundação para a Ciência e a Tecnologia (PTDC/BIM-MED/0032/2014, PRECISE - LISBOA-01-0145-FEDER-016394, LISBOA-01-0145-FEDER-028534)
Received: 14 November 2018
Accepted: 19 July 2019
First Online: 5 August 2019
Ethics approval and consent to participate
: Animal experiments were performed according to EU regulations and approved by the Animal Ethics Committee of Instituto de Medicina Molecular –João Lobo Antunes (iMM-JLA). The animal facility of iMM-JLA complies with the Portuguese law for the use of laboratory animals (Decreto-Lei 113/2013); and follows the European Directive 2010/63/EU and the FELASA (Federation of European Laboratory Animal Science Associations) guidelines and recommendations concerning laboratory animal welfare.
: Not applicable.
: The authors declare that they have no competing interests.