Funding for this research was provided by:
Staatssekretariat für Bildung, Forschung und Innovation (No grant number applies)
Merck KGaA, Darmstadt, Germany (No grant numer applies)
Received: 13 October 2019
Accepted: 11 February 2020
First Online: 28 February 2020
Ethics approval and consent to participate
: The ethical committees (EC) for the approval of the trial (with reference numbers were applicable) were as follows, Tables InternalRef removed and InternalRef removed:In Germany the ECs for the respective institutions were as in Table InternalRef removed:The trial was registered at EU Clinical Trials Register (EudraCT- Nr: 2009–016584-10) and ExternalRef removed under NCT01107639.All patients gave their written consent for participation in this trial. Table removedTable removed
: Not applicable.
: Co-author Thomas Ruhstaller is an Associate Editor of this journal. All other authors declare that they have no competing interests.