Funding for this research was provided by:
National Cancer Research Institute (LCSuPaC 30)
Received: 25 March 2021
Accepted: 17 June 2021
First Online: 12 July 2021
: Ethical approval for the trial protocol (ultimately Version 3.0 dated 02-April-2014) was obtained from the Black Country Research Ethics Committees (now West Midlands – The Black Country) and the following local institutional review boards: Sandwell and West Birmingham Hospitals NHS Trust – City Hospital; Heart of England NHS Foundation Trust - Birmingham Heartlands Hospital; University Hospitals Birmingham NHS Foundation Trust - Queen Elizabeth Hospital, and; The Dudley Group of Hospitals NHS Foundation Trust - Russells Hall Hospital. The trial was performed in accordance with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. All patients provided written informed consent.
: Not applicable.
: All authors declare no competing interests.