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Article History

Received: 1 July 2021

Accepted: 9 June 2022

First Online: 21 June 2022

Declarations

:

: This study was conducted in accordance with the Helsinki Declaration, it also was approved by the ethic committee of Hainan General Hospital and the consent from the patients’ family members, the researchers provided sufficient information and guarantee of participation. All patients’ families were fully aware of our purpose and method of this study, they had the right to reject the new dose without any reason. The privacy of the study participants must be protected and all participants were anonymous. Written informed consent was obtained from all patients’ family members.

: Not applicable.

: The authors declare that they have no competing interests.