Document is current

Article History

Received: 10 March 2017

Accepted: 14 December 2017

First Online: 8 February 2018

Ethics approval and consent to participate

: The central Ethics Committee that approved the study was the Niño Jesús Hospital Committee (Madrid), and all children/adolescents and their legal representatives signed a written informed consent form prior to participation in the study.

: Not applicable.

: JQ: participated as speaker and/or acted as consultant for Grunenthal, Lilly, Shire, MSD, Janssen & Ferrer; received unrestricted educational and research support from Mutua Madrileña and Otsuka. JAR-Q: on the speakers bureau and/or acted as consultant for Eli Lilly, Novartis, Shire, Lundbeck, Ferrer, Medice, and Rubió; received travel awards from Rubió, Ferrer, Shire, and Eli Lilly; received unrestricted educational and research support from Eli Lilly, Shire, Rovi, Ferrer, Lundbeck, and Rubió. FM: received funding for collaborations for congress organization from Shire, Rubió, and Rovi. AF-J: received economic support to attend courses/congresses from Janssen, Eli Lilly, Rubio, Juste, Shire, and Otsuka; received fees for participation in medical congresses from Janssen, Eli Lilly, Rubio, Juste, and Shire; participated in advisory boards for Janssen, Eli Lilly, and Shire; received grants from Janssen, Eli Lilly, Rubio, and Shire. JM-R: received honoraria for being a speaker and acting on advisory boards from Shire and Janssen Pharmaceuticals. CS: received non-personal research funds for his department from Caja Navarra Foundation, Lundbeck, Shire, and Teva; served as consultant for Alicia Koplowitz Foundation, Editorial Médica Panamericana, Eli Lilly, EUNETHYDIS, Instituto de Salud Carlos III, Medice/Juste, NeuroTech Solutions Ltd., Rubió, and Shire; served on speakers bureaux on continuous medical education for Eli Lilly, Shire, Universidad Internacional Menéndez Pelayo, and Universidad Internacional de La Rioja (UNIR); received royalties from DOYMA, Editorial Médica Panamericana, and Mayo Ediciones. MT: received grant/research support from Shire Pharmaceuticals S.L., Rubio, Rovi, and Janssen. MP: participated as speaker for Lilly, Shire, and Rovi. JC: received consulting income and research support from Janssen, Shire, Ferrer, Lilly, and Lundbeck. JS and LG-O are employees of Shire. JSS, MGG, MG, MJM, and JE received support from Shire for this research. JAA: acted as consultant to or received honoraria or grants from Eli Lilly, Shire, Janssen Cilag, Rovi, Spanish Ministry of Health, Instituto de Salud Carlos III, Agència d’Informació, Avaluació i Qualitat en Salut (AIAQS), and the Alicia Koplowitz Foundation.

: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.