Funding for this research was provided by:
Bundesministerium für Bildung und Forschung (BMBF 01EO1503)
Stiftung Rheinland-Pfalz für Innovation (AZ 961-386261/733)
Received: 23 January 2018
Accepted: 31 March 2019
First Online: 24 April 2019
Ethics approval and consent to participate
: The study protocol and study documents were approved by the local ethics committee of the Medical Chamber of Rhineland-Palatinate, Germany (reference no. 837.020.07; original vote: 22.3.2007, latest update: 20.10.2015) and by the local and federal data safety commissioners. Informed consent was obtained written by all participants of the GHS.
: Not Applicable.
: The authors declare that they have no competing interests.
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