Funding for this research was provided by:
Department of Defense Global Emerging Infection Surveillance (P0220_13_OT)
Received: 2 March 2020
Accepted: 25 June 2020
First Online: 6 July 2020
Ethics approval and consent to participate
: This protocol was reviewed and approval by Institutional Review Boards (IRBs) at SUNY Upstate Medical University (417710–27), the Luis Vernaza Hospital in Guayaquil, Ecuador (HLV-DOF-CEISH-003), and the Ecuador Ministry of Health. Prior to study start, all study subjects engaged in a written informed consent or assent process, as applicable. In the event the subject was unable to participate in the informed consent/assent process, an adult representative documented their consent, as approved the ethics committee. Children aged 7–17 years signed an assent statement and parents signed an informed consent. Parents signed an informed consent on behalf of children aged greater than 6 months to less than 7 years. The study included children (> 6 months) to adults (index cases) who were evaluated in sentinel clinics or the hospital with a clinical diagnosis of acute DENV infection. Before signing the informed consent, index cases were informed that they might be randomly selected to participate in a cluster investigation. Additional study subjects included children (> 6 months) and adults, who resided in the cluster homes.
: Not applicable.
: The authors declare no competing interests, financial or non-financial.