Sauceda, John A.
Lechuga, Julia
Ramos, Maria Elena
Puentes, Jorge
Ludwig-Barron, Natasha
Salazar, Jorge
Christopoulos, Katerina A.
Johnson, Mallory O.
Gomez, David
Covarrubias, Rogelio
Hernandez, Joselyn
Montelongo, David
Ortiz, Alejandro
Rojas, Julian
Ramos, Luisa
Avila, Itzia
Gwadz, Marya V.
Neilands, Torsten B.
Funding for this research was provided by:
National Institute on Drug Abuse (R01DA053659, R01DA053659, R01DA053659, R01DA053659, R01DA053659, R01DA053659)
Article History
Received: 4 November 2022
Accepted: 31 January 2023
First Online: 10 February 2023
Declarations
:
: The authors have no conflicts of interests.
: HIV care continuum engagement on the U.S.-Mexico Border among PWID is seriously impeded by contextual factors such as drug use stigma, mobility, policing, violence, and access to opiates.Interventions for PWIDLH are typically tested as “packaged” interventions with multiple components, which obscures the effect of each component, does not provide data on how to refine each component to achieve sustained HIV viral suppression, and may lead to inefficient interventions with inactive or counter-productive components.This study will use the multiphase optimization strategy and an efficient factorial design to estimate the individual and interactive impact of four established intervention components for HIV viral suppression in a real-world setting.Based on findings, we will then design a new efficient multi-component intervention with no inactive or poorly performing components and constraints in place to facilitate its scalability.
: The study was approved by the University of Texas at El Paso Institutional Review Board on January 19, 2022 and the University of California, Los Angeles Addiction Medicine Data and Safety Monitoring Board in June of 2022. Informed consent will be provided by participants prior to the study enrollment. All research involving human participants will be performed in accordance with the Declaration of Helsinki and has been approved by an appropriate ethics committee and data and safety monitoring board.
: Not applicable.
: The authors have no competing interest.