Received: 23 December 2020
Accepted: 12 April 2021
First Online: 5 May 2021
: Not applicable.
: Informed written consent was obtained for all participants in the study. The study was approved by the Health Research Authority and Research Ethics Committees (IRAS 223450). All methods were carried out in accordance with relevant guidelines and regulations.
: Richard Davis(RD) is an employee of Boehringer Ingelheim (BI). This project was undertaken independently by RD as part of a MsC with the University of Bristol. BI had no part in the concept or undertaking of this project. Dr Barratt has received consultancy fees from Boehringer Ingeleheim, separate to the submitted work. No other conflicts of interests are declared.