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Article History

Received: 5 December 2021

Accepted: 29 September 2022

First Online: 19 November 2022

Declarations

:

: The Danish Data Protection Agency have approved the use of the Danish National Health Data for use in this study, in a anonymized form. The use of anonymized registry data does not require ethical approval in Denmark. The study was approved by the Danish Data Protection Agency (ID: no. P-2019-191).

: These data are anonymized – it is a true register-based study of 5–6 mio inhabitants of Denmark - and we have never met a patient, never performed examinations, we only have data from the National diagnosis registry with ICD-10 codes and the prescription registry with all ACT codes which is without any relation to persons.

: All authors, except from MD Mette Kehlet from MSD, have no conflict of interest. But all analysis and Tables are performed individually by the several of the authors and reviewed by the last author who have re-calculated all data analysis. The first author has written the manuscript from start to the end.Mette Kehlet, MD, is employed at 4) MSD Denmark, Havneholmen 25, 1561 Copenhagen V, Denmark. MSD have read the manuscript before submission, but I have had the responsibility for the manuscript, the research, the analysis, the figures, and the tables.”