Funding for this research was provided by:
Arthritis Research UK (20380)
National Institutes of Health (P60-AR047785)
Special Strategic Award (18676)
National Institute for Health Research Biomedical Research Unit Funding Scheme
Manchester Academic Health Sciences Centre
Received: 24 April 2017
Accepted: 24 July 2017
First Online: 10 August 2017
Ethics approval and consent to participate
: The study was approved by the Central Manchester Local Research Ethics Committee (Ethics number 09/H1012/35) and Wellcome Trust Clinical Research Facility, Scientific Advisory Board. Subjects provided written consent before randomisation. (UK. ISRCTN50380458.)Datasets analysed from the study are available from the corresponding author on request.
: Not applicable.
: The authors declare that they have no competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.