Funding for this research was provided by:
Ministry of Health, Labour and Welfare (14020301-01)
Received: 3 February 2017
Accepted: 22 February 2018
First Online: 2 March 2018
Ethics approval and consent to participate
: Ethical approval was obtained from the ethical committee of The University of Tokyo [Approval number: 10665-(1)]. All participants gave their consent electronically and were compensated. No personally identifiable information was collected.
: Not applicable
: KM received the research grant from Ministry of Health, Labour and Welfare for the submitted work; grant support including an endowed chair from Sumitomo Dainippon Pharma Co., Ltd. and OKAMURA CORPORATION; grant support including an endowed chair and lecture fees from AYUMI Pharmaceutical Corporation, Nippon Zoki Pharmaceutical Co., Ltd., ONO PHARMACEUTICAL CO., LTD., Eli Lilly Japan K.K., Astellas Pharma Inc., TOTO LTD., and Eisai Co., Ltd.; lecture fees from Pfizer Japan Inc., HISAMITSU PHARMACEUTICAL CO., INC., Janssen Pharmaceutical K.K., KAKEN PHARMACEUTICAL CO., LTD., TEIJIN PHARMA LIMITED; and lecture fees and advisory fees from Shionogi & Co., Ltd., outside the submitted work. HO, YO, HC, YT, YM, and AFM have nothing to disclose. MK, ES, HM, and TL are employed by Clinical Study Support, Inc.. ST received personal fees for expert testimony from Amgen inc., ASAHI KASEI PHARMA CORPORATION, Amgen Astellas BioPharma K.K., ONO PHARMACEUTICAL CO., LTD., KYOCERA Medical Corporation, DAIICHI SANKYO COMPANY, LIMITED, TEIJIN PHARMA LIMITED., Eli Lilly Japan K.K., and Pfizer Japan inc.; endowments from Astellas Pharma Inc., AYUMI Pharmaceutical Corporation, Pfizer Japan inc., Bristol-Myers Squibb, DAIICHI SANKYO COMPANY, LIMITED, and Chugai Pharmaceutical Co., Ltd.; and grants from The Japan Agency for Medical Research and Development (AMED), Japan -Society for the Promotion of Science (JSPS)/ Grant-in-Aid for Scientific Research (A), and Japan Society for the Promotion of Science (JSPS)/ Grant-in-Aid for Exploratory Research outside the submitted work.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.