Received: 12 June 2019
Accepted: 23 January 2020
First Online: 4 February 2020
Ethics approval and consent to participate
: Study participants are briefed about the study. Participants will only be included in the study with signed informed consent. The study protocol was respectively registered via DRKS Data Management (German Clinical Trials Register, ID: DRKS00012744) and approved by the responsible ethics committee (Ethics Committee of the Medical Association Westphalia-Lippe and of the Faculty of Medicine of the University of Münster) on 2018-11-15 with the approval number 2017–329-f-S.
: Not applicable.
: JO: In the last 5 years I have received lecture honoraria from Pfizer, Grünenthal and Mundipharma.NN: In the last 5 years I have received lecture honoraria from Grünenthal and Mundipharma.All other authors declare no competing interests.