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Randomised, double-blind comparison of a fixed co-formulation of intra-articular polynucleotides and hyaluronic acid versus hyaluronic acid alone in the treatment of knee osteoarthritis: two-year follow-up

Crossref DOI link: https://doi.org/10.1186/s12891-021-04648-0

Published Online: 2021-09-12

Published Print: 2021-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Stagni, Cesare

Rocchi, Martina

Mazzotta, Alessandro

Del Piccolo, Nicolandrea

Rani, Nicola

Govoni, Marco

Vivarelli, Leonardo

Veronesi, Francesca

Fini, Milena

Dallari, Dante
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Article History

Received: 18 January 2021

Accepted: 12 August 2021

First Online: 12 September 2021

Declarations

:

: The Institutional Review Board of the Rizzoli Orthopedic Institute reviewed all study materials such as study protocol, informed consent forms, electronic clinical report form, CVs of authors, Etc. for ethical problems. All relevant documents (IRB approval certificate and approved study materials) are available from Dr. Dante Dallari or the corresponding author, Martina Rocchi, MD, on request. The principles of the Declaration of Helsinki were always respected. The study was registered in theExternalRef removeddatabase of privately and publicly funded clinical studies conducted worldwide (ExternalRef removedIdentifier: NCT02417610).

: The manuscript contains no individual patient’s data in any form—all authors consent to the manuscript’s publication.

: The authors declare that they have no competing or conflicts of interest.

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