Funding for this research was provided by:
Received: 10 April 2019
Accepted: 25 September 2019
First Online: 16 October 2019
Ethics approval and consent to participate
: The study was conducted in accordance with the Declaration of Helsinki including all amendments, and was approved by the Ethics Committee of Hospital Universitario 12 de Octubre (Madrid, Spain) as ethical reference committee. All patients gave written informed consent before their inclusion in the study, and their treatment followed routine clinical guidelines. All sites involved approved the study by their ethics committee (see list of sites in additional file InternalRef removed).
: Not applicable.
: ARA, LMP, MEJ, JBG, DLB and FGV have received a speaker or consultant fee from Janssen, Astellas and Bayer. They do not present a conflict of interest specifically for the realization of this article.JMT and AGG are employees of Janssen Cilag-Spain.