Funding for this research was provided by:
Institute of Biomedical Science
Betsi Cadwaladr University Health Board
Received: 27 April 2020
Accepted: 4 August 2020
First Online: 14 August 2020
Ethics approval and consent to participate
: Written ethics committee approval (reference: REC4:12/WA/0117) was obtained from the Welsh Research Ethics Committee 4 with a Helsinki declaration. The study was undertaken at the BCUHB Wrexham Maelor Hospital and the North Wales Clinical Research Centre, with the study being sponsored by the University of Chester (UK). Written informed consent for the study was received from all patients.
: Not Applicable.
: The authors declare that they have no competing interests.