Received: 19 February 2021
Accepted: 11 August 2021
First Online: 2 September 2021
: The CPRD has obtained ethical approval from a National Research Ethics Service Committee (NRES), for all purely observational research using anonymized CPRD data; namely, studies which do not include patient involvement. The independent scientific advisory committee is responsible for reviewing protocols for scientific quality, but may recommend that study-specific ethical approval is sought if ethical issues arise in relation to an individual study. This study met the requirements under the CPRD obtained ethical approval from NRES. Only de-identified data were obtained, and patients could opt out if they did not wish to have their data used for research purposes.
: Not applicable.
: MA, ML and PJOC are employees of Astellas Pharma Europe Ltd.; NC was an employee of Astellas Pharma Europe Ltd. when the manuscript was written; MA and AJ were working as associates as part of the Knowledge Transfer Partnership (KTP) between Astellas and Manchester Metropolitan University during the time this research was carried out; FF received grant funding from Astellas Pharma during the conduct of the study; RvM was an employee of Astellas Global Development, Leiden at the time of this work.