Funding for this research was provided by:
National Institute of Diabetes and Digestive and Kidney Diseases
Received: 13 October 2021
Accepted: 10 March 2022
First Online: 6 April 2022
: The institutional review boards of each clinical center (University of Washington School of Medicine, University of Texas Southwestern Medical Center, Washington University School of Medicine, Children’s Hospital of Philadelphia, and University of Pennsylvania) reviewed and approved the study. All procedures involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants age 18 or above included in the study. Parents provided informed consent for all minor participants (age < 18 years, per the Institutional Review Boards governing this study), along with the assent of each adolescent participant.
: Not applicable.
: Dr. Antonelli has relationships with the following entities: Boston Scientific Corp, Cook Medical (Advisory Board). Dr. Tasian has relationships with the following entities: Dicerna (advisory board, scientific study), Alnylam (advisory board), Novome (advisory board), and Allena Pharmaceuticals (consultant). No other authors reported disclosures relevant to this study.