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An effective combination of codon optimization, gene dosage, and process optimization for high-level production of fibrinolytic enzyme in Komagataella phaffii (Pichia pastoris)

Crossref DOI link: https://doi.org/10.1186/s12896-020-00654-7

Published Online: 2020-12-04

Published Print: 2020-12

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Che, Zhiqun

Cao, Xiaoyan

Chen, Guiguang

Liang, Zhiqun
Funding

Funding for this research was provided by:

the National Natural Science Foundation of China (31560448, 21062001)

the Natural Science Foundation of Guangxi (2016GXNSFAA380130)
License Information

Text and Data Mining valid from 2020-12-01

Version of Record valid from 2020-12-04
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Article History

Received: 6 August 2020

Accepted: 5 November 2020

First Online: 4 December 2020

Ethics approval and consent to participate

: Not applicable.

: Not applicable.

: The authors declare that they have no competing interests

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