Funding for this research was provided by:
USZ Innovation (INOV00006, INOV00017)
Received: 8 May 2018
Accepted: 18 October 2018
First Online: 29 October 2018
Ethics approval and consent to participate
: All patients included in the observational pilot study gave informed written consent for research use of their tissue samples, based on the approved consent forms of the University Hospitals Zurich and Basel. In Zurich, surplus tumor material was obtained after surgical removal of melanoma metastases from patients after written informed consent approved by the local IRB (EK647 and EK800). In addition, a specific approval was given for this research project (KEK-ZH.2014–0425) by the Kantonal Ethics Commission of Zürich, Stampfenbachstrasse 121, Zürich Switzerland 8090, and the Ethical Committee of Northwestern and Central Part of Switzerland, EKNZ. The retrospective use of the pseudonymized data in Basel did not require written informed consent from individual patients. Pseudonymized clinical data only from patients that have signed a general consent statement of the University Hospital Basel were used for this study. Clinical data of patients from the University Hospital Basel were collected by SR and AW, staff members at the respective institution. All research on human patients followed the standards set by the Declaration of Helsinki on human rights, and the biobank samples were handled according to the international guidelines set by the Declaration of Taipei.
: Not applicable.
: SIR: Research support: AbbVie, AstraZeneca, BMS, Merck; Honoraria for advisory boards (to the institution): Abbvie, AstraZeneca, BMS, Eisai, Merck, MSD, Novartis, Pfizer, Roche, Takeda.DJS: Honoraria for scientific advisory board at BC Platforms.All other authors declare that they have no competing interests.
: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.