Verboven, Lennert
Calders, Toon
Callens, Steven
Black, John
Maartens, Gary
Dooley, Kelly E.
Potgieter, Samantha
Warren, Robin M.
Laukens, Kris
Van Rie, Annelies
Funding for this research was provided by:
Fonds Wetenschappelijk Onderzoek (1S39119N, G0F8316N)
U.S. Food and Drug Administration (R01FD005724)
National Institute of Allergy and Infectious Diseases (K24AI150349)
South African Medical Research Council
Department of Science and Innovation - National Research Foundation, South Africa
Article History
Received: 2 February 2021
Accepted: 22 February 2022
First Online: 2 March 2022
Declarations
:
: The research was performed in accordance with the Declaration of Helsinki. Collection of the clinical strains and the determination of the genotypic drug resistance profile was approved by appropriate ethics committees. For the training dataset, ethical approval was obtained from the Human Research Ethics Committee of the University of the Witwatersrand in South Africa and the Institutional Review Board of the University of North Carolina at Chapel Hill in the United States (reference numbers M111139 and 11-2273). Approval of study activities was also obtained from relevant health authorities. Participants gave verbal informed consent by phone (recorded). The Research Ethics Committee or Institutional Review Board of Human Research Ethics Committee of the University of the Witwatersrand in South Africa (M111139) and the Institutional Review Board of the University of North Carolina at Chapel Hill in the United States (11-2273) waived the need of informed consent for patients who had died or were lost to follow-up from TB care prior to study enrolment and could not be contacted despite multiple attempts. For the validation dataset, ethical clearance was obtained from Stellenbosch University Health Research Ethics Committee. This ethics approval (ref number N09/11/269) has a waiver of informed consent. The study titled "a personalized recommender system for whole genome sequencing-based individualized treatment for drug resistant tuberculosis" reported in this manuscript was approved by the Ethics Committee of the University Hospital Antwerp and the University of Antwerp (ref number 2107101).
: Not applicable.
: Not applicable.