Funding for this research was provided by:
Received: 6 April 2017
Accepted: 19 February 2018
First Online: 1 March 2018
Ethics approval and consent to participate
: The study protocol was approved by the appropriate institutional review board or independent ethics committee for each study site. Informed consent was collected for patients from Italy and Spain who were alive at the time of data abstraction; an informed consent form was not required from deceased patients’ next of kin. In the other countries, informed consent was not required for working with the de-identified retrospective data used in the study. The names and locations of the ethics committees are summarized in the Additional file InternalRef removed.
: Not applicable.
: Dae Ho Lee reports honoraria from AstraZeneca, Boehringer-Ingelheim, Bristol-Myers Squibb, CJ Healthcare, Eli Lilly, Jansen, Merck, MSD, Mundipharma, Novartis, Ono, Pfizer, Roche, Samyang Biopharm, and ST Cube for participating in advisory boards; and receipt of consulting fees from the Ministry of Food and Drug Safety (MFDS), Korea, and Health Insurance Review and Assessment Service (HIRA), Korea.Hiroshi Isobe has received payment for speaking engagements from AstraZeneca, Bristol-Myers Squibb, Kyowa Hakko Kirin, Chugai, Boehringer Ingelheim, Ono Pharmaceutical Co. Ltd., and Eli Lilly Japan, K.K.Hubert Wirtz reports lecture fees from AstraZeneca, Roche, and Boeringer Ingelheim. Filippo de Marinis reports advisory role for Roche, BMS, and AstraZeneca.Ann-Marie Woodgate and Nello Donnini are employees of Merck Sharp & Dohme.Min Huang, Ashwini Arunachalam, and Smita Kothari are employees of Merck & Co., Inc..Xiting Cao, is an employee of Merck & Co., Inc. and owns stock options from Merck.The other authors have no competing of interest to declare.
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