Funding for this research was provided by:
Orphan Technologies (NA)
Received: 9 December 2019
Accepted: 28 February 2020
First Online: 6 March 2020
Ethics approval and consent to participate
: All study data were accessed with protocols compliant with US patient confidentiality requirements, including the Health Insurance Portability and Accountability Act of 1996 regulations (HIPAA). As all databases used in the study are fully de-identified and compliant with the HIPPA, this study was exempted from Institutional Review Board approval and informed consent was not needed.
: Not applicable.
: MS and FG are employed by Orphan Technologies. DI, KE and CL are employed by IBM Watson Health as consultants and received funding from Orphan Technologies to conduct this study. DL is a paid consultant of Orphan Technologies.