Funding for this research was provided by:
Text and Data Mining valid from 2019-04-05
Received: 19 November 2018
Accepted: 21 March 2019
First Online: 5 April 2019
Ethics approval and consent to participate
: The protocol for this research was approved by the Independent Scientific Advisory Committee (ISAC) for MHRA Database Research (protocol number 17_083). Generic ethical approval for observational research using CPRD with approval from ISAC has been granted by a Health Research Authority (HRA) Research Ethics Committee (East Midlands – Derby, REC reference number 05/MRE04/87). Linked pseudonymised data was provided for this study by CPRD. Data is linked by NHS Digital, the statutory trusted third party for linking data, using identifiable data held only by NHS Digital. Select practices consent to this process at a practice level with individual patients having the right to opt-out.
: Not applicable.
: All authors have completed the ICMJE uniform disclosure form at ExternalRef removed and declare the following. LS reports grants from Wellcome Trust during the conduct of the study; outside the submitted work, LS reports grants from Wellcome, MRC, NIHR, BHF and Diabetes UK and grants and personal fees from GlaxoSmithKline. JKQ, outside the submitted work, reports grants from The Health Foundation, MRC, and British Lung Foundation; grants and personal fees from GlaxoSmithKline; grants and personal fees from Boehringer Ingelheim; grants and personal fees from AstraZeneca; grants and personal fees form Chiesi; personal fees from Teva; grants and personal fees from Insmed; grants and personal fees from Bayer and grants from IQVIA.
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