Funding for this research was provided by:
National Institute for Health Research (HPRU-2012-10041)
Medical Research Council (MR/M003736/1)
Received: 17 January 2019
Accepted: 12 July 2019
First Online: 4 September 2019
Ethics approval and consent to participate
: The review of endocarditis cases 2010–2016 was performed as part of a clinical audit approved by the Oxford University Hospitals Clinical Audit Service (Datix number 4168) and used data from an NHS data warehouse. The 1999–2016 analysis was conducted using an anonymised extract of linked admissions to and microbiology data from the Oxford University Hospitals NHS Foundation Trust from the Infections in Oxfordshire Research Database (IORD) which has generic Research Ethics Committee, Health Research Authority and Confidentiality Advisory Group approvals (14/SC/1069, ECC5-017(A)/2009). The Leeds analysis was conducted as a service evaluation exercise and approved by the local cardiology audit lead.
: Not applicable.
: NJF reports grants from the Medical Research Council and National Institute of Health Research during the conduct of the study. LP, BY, PQ, TEAP, DMC and ASW report grants from the National Institute of Health Research during the conduct of the study. JW, RG, CM, SW, BMP and AJ declare that they have no competing interests. JS reports grants from National Institute for Health Research, grants from Medical Research Council, grants from Engineering and Physical Sciences Research Council and grants and non-financial support from British Society for Antimicrobial Chemotherapy outside the submitted work.