Funding for this research was provided by:
Broad Institute (Next Gen Fund)
National Science Foundation (GRFP 2015214731)
National Institute of Allergy and Infectious Diseases (F31 AI122592)
National Center for Advancing Translational Sciences (R21 TR003040)
Received: 10 March 2020
Accepted: 27 April 2020
First Online: 18 June 2020
Ethics approval and consent to participate
: This study was approved by the Partners Institutional Review Board (#2017P000214). Written informed consent was obtained from all participants.
: Not applicable.
: SEA has received honoraria and/or travel expenses for lectures from Abbvie, Biogen, EIP Pharma, Roche, and Sironax; has received fees for consulting and/or advisory boards from Athira, Biogen, Cassava, Cognito, Cortexyme, Sironax, and vTv; and has received grant support from Abbvie, Amylyx, EIP Pharma, and Merck. SMV has received speaking fees from Illumina and has received research support in the form of unrestricted charitable contributions from Charles River Laboratories and Ionis Pharmaceuticals. EVM has received research support in the form of unrestricted charitable contributions from Charles River Laboratories and Ionis Pharmaceuticals and has consulted for Deerfield Management and Guidepoint. KB holds the Torsten Söderberg Professorship; has served as a consultant or on advisory boards for Abcam, Axon, Biogen, Lilly, MagQu, Novartis and Roche Diagnostics; and is a cofounder of Brain Biomarker Solutions in Gothenburg AB, a GU Ventures-based platform company at the University of Gothenburg. HZ is a Wallenberg Academy Fellow, a cofounder of Brain Biomarker Solutions in Gothenburg A.B., and a GU Ventures-based platform company at the University of Gothenburg and has served on advisory boards for Roche Diagnostics, Wave, Samumed, and CogRx.