Funding for this research was provided by:
NIHR Bristol Biomedical Research Centre
British Heart Foundation (AA/18/7/34219)
National Institute for Health Research Senior Investigator award (NF-0616-10102)
Medical Research Council (MC_UU_00011/6)
Received: 25 March 2020
Accepted: 7 July 2020
First Online: 31 August 2020
Ethics approval and consent to participate
: NHS Health Research Authority provided ethical approval for the study. REC reference 16/WM/0308. IRAS project ID:202216. All participants provided signed consent.
: Not applicable
: No funding bodies had any role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. SMN has participated in Advisory Boards and received speaker’s fees from Beckman Coulter, Ferring, Finox, Merck, MSD and Roche Diagnostics. DAL has received grant funding for other studies, not related to this one, from government, charity and industry funders, including Roche Diagnostics and Medtronic. DAL is a member of the Editorial Board for BMC Medicine.