Funding for this research was provided by:
Frances and Augustus Newman Foundation (N/A)
Wellcome Trust (99148)
UCL Cancer Institute Research Trust (N/A)
Dangoor Education (N/A)
National Institute for Health Research UCLH Biomedical Research Centre (BRC369/CN/SB/101310)
Michael Chowen CBE DL and Maureen Chowen (N/A)
MRC Proximity to Discovery Industry Engagement Fund (530912)
Text and Data Mining valid from 2018-11-27
Received: 12 October 2018
Accepted: 17 October 2018
First Online: 27 November 2018
: <b>Consortium members</b>Stephan Beck<sup>1, 2, 3</sup>, Alison M Berner<sup>1</sup>, Graham Bignell<sup>4</sup>, Maggie Bond<sup>4</sup>, Martin J Callanan<sup>4</sup>, Olga Chervova<sup>1</sup>, Lucia Conde<sup>5</sup>, Manuel Corpas<sup>4, 6</sup>, Simone Ecker<sup>1</sup>, Hannah R Elliott<sup>7, 8</sup>, Silvana A Fioramonti<sup>1</sup>, Adrienne M Flanagan<sup>9</sup>, Ricarda Gaentzsch<sup>10</sup>, David Graham<sup>11</sup>, Deirdre Gribbin<sup>4</sup>, José Afonso Guerra-Assunção<sup>5</sup>, Rifat Hamoudi<sup>12, 13</sup>, Vincent Harding<sup>14</sup>, Paul L Harrison<sup>15</sup>, Javier Herrero<sup>5</sup>, Jana Hofmann<sup>16</sup>, Erica Jones<sup>4</sup>, Saif Khan<sup>12</sup>, Jane Kaye<sup>17, 18</sup>, Polly Kerr<sup>19</sup>, Emanuele Libertini<sup>1</sup>, Lauren Marks<sup>20</sup>, Laura McCormack<sup>21</sup>, Ismail Moghul<sup>1</sup>, Nikolas Pontikos<sup>4</sup>, Sharmini Rajanayagam<sup>22</sup>, Kirti Rana<sup>5</sup>, Momodou Semega-Janneh<sup>4</sup>, Colin P Smith<sup>4, 23</sup>, Louise Strom<sup>24</sup>, Sevgi Umur<sup>1</sup>, Amy P Webster<sup>1</sup>, Elizabeth H Williams<sup>10</sup>, Karen Wint<sup>4</sup>, John N Wood<sup>4,25</sup>.<b>Affiliations</b><sup>1</sup>Medical Genomics, UCL Cancer Institute, London WC1E 6BT, UK.<sup>2</sup>Institute of Digital Health, University College London, London WC1E 6BT, UK.<sup>3</sup>Institute for Precision Medicine, University College London, London WC1E 6BT, UK.<sup>4</sup>UK Citizen.<sup>5</sup>Bill Lyons Informatics Centre, UCL Cancer Institute, London WC1E 6BT, UK.<sup>6</sup>Cambridge Precision Medicine Ltd., Future Business Centre, King’s Hedges Road, Cambridge CB4 2HY, UK.<sup>7</sup>MRC Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK.<sup>8</sup>Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1TH, UK.<sup>9</sup>Head of Pathology, UCL Cancer Institute, London WC1E 6BT, UK.<sup>10</sup>Seven Bridges Genomics Inc., 1 Main St, 5th Floor, Suite 500, Cambridge MA 02142, USA.<sup>11</sup>University College London Hospital, 235 Euston Road, London, NW1 2BU, UK.<sup>12</sup>Division of Surgery and Interventional Science, University College London, London WC1E 6BT, UK.<sup>13</sup>Sharjah Institute of Medical Research, College of Medicine, University of Sharjah, Sharjah, UAE.<sup>14</sup>UCL Health Creatives, 30 Guilford Street, London WC1N 1EH, UK.<sup>15</sup>Visual Research Centre, Duncan of Jordanstone College of Art and Design, University of Dundee DD1 4DY, UK.<sup>16</sup>Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, DE.<sup>17</sup>Centre for Health, Law and Emerging Technologies (HeLEX), Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK.<sup>18</sup>Melbourne Law School, University of Melbourne, 185 Pelham Street, Carlton Victoria 3053, Australia.<sup>19</sup>NIHR Oxford Biomedical Research Centre, The Churchill Hospital, Oxford OX3 7LE, UK.<sup>20</sup>Division of Biosciences, University College London, London WC1E 6BT, UK.<sup>21</sup>Permanent UK Resident.<sup>22</sup>The Royal Australian College of General Practitioners, 100 Wellington Parade, East Melbourne, VIC 3002, AU.<sup>23</sup>School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ, UK.<sup>24</sup>Arnold & Porter Kaye Scholer LLP, London WC2B 5PQ, UK.<sup>25</sup>Molecular Nociception Group, WIBR, University College London, London WC1E 6BT, UK.<b>Project coordination</b>Stephan Beck, Olga Chervova, Lucia Conde, José Afonso Guerra-Assunção, Rifat Hamoudi, Paul L Harrison, Javier Herrero, Erica Jones, Jane Kaye, Ismail Moghul, Amy P Webster.<b>IT systems</b>Olga Chervova, Ricarda Gaentzsch, Javier Herrero, Rifat Hamoudi, Vincent Harding, Ismail Moghul, Sevgi Umur, Elizabeth H Williams.<b>Data Analysis</b>Lucia Conde, Simone Ecker, Silvana A Fioramonti, José Afonso Guerra-Assunção, Rifat Hamoudi, Javier Herrero, Emanuele Libertini, Ismail Moghul, Nikolas Pontikos, Kirti Rana, Amy P Webster.<b>Support</b>Alison M Berner, Hannah R Elliott, Adrienne M Flanagan, David Graham, Jana Hofmann, Saif Khan, Polly Kerr, Lauren Marks, Sharmini Rajanayagam, Louise Strom.<b>Citizen science</b>Graham Bignell, Maggie Bond, Martin J Callanan, Manuel Corpas, Deirdre Gribbin, Laura McCormack, Nikolas Pontikos, Momodou Semega-Janneh, Colin P Smith, Karen Wint, John N Wood.<b>Manuscript</b>Stephan Beck wrote the manuscript with contributions from all authors. All authors have approved the manuscript. Corresponding author: Stephan Beck (firstname.lastname@example.org).<b>Links</b>PGP-UK: ExternalRef removedPGP-UK Data: ExternalRef removedGenoME app: ExternalRef removedGlobal PGP Network: ExternalRef removedOpen Humans: ExternalRef removedDNA.Land ExternalRef removedEBI: ExternalRef removedEnsembl Glossary: ExternalRef removedRepositive: ExternalRef removedSeven Bridges Genomics: ExternalRef removedPGP-UK data in Seven Bridges Genomics cloud:ExternalRef removed1000 Genomes Project: ExternalRef removedSNPedia: ExternalRef removedExAC: ExternalRef removedgnomAD: ExternalRef removed/.GetEvidence: ExternalRef removedClinVar: ExternalRef removedPGP-UK social media:Twitter: ExternalRef removedFacebook: ExternalRef removedYouTube: ExternalRef removedBlog: ExternalRef removed
: The research conformed to the requirements of the Declaration of Helsinki, UK national laws and to UK regulatory requirements for medical research. All participants were informed, consented, subjected to an online entrance exam and enrolled as described on the PGP-UK sign-up web site (ExternalRef removed). The study was approved by the UCL Research Ethics Committee (ID Number 4700/001) and is subject to annual reviews and renewals. PGP-UK participants uk35C650, uk33D02F, uk481F67 and uk4CA868 all self-identified and consented for their names, photos, videos and data to be used in the manuscript and GenoME app.
: All authors have approved the manuscript for publication. In addition, PGP-UK participant uk35C650 has self-identified and consented for his photo to be used.
: All authors declare that they have no competing interests.
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