Funding for this research was provided by:
Allen Foundation (Discovery Center for Human Brain Evolution)
National Institute of Neurological Disorders and Stroke (RO1 35129)
National Institutes of Health (K08AG065502, T32HL007627)
JSPS London (BRF1900016)
Stuart H.Q. and Victoria Quan Fellowship in Neurobiology
Received: 3 November 2020
Accepted: 3 February 2021
First Online: 12 February 2021
Ethics approval and consent to participate
: Research on human samples was conducted following written informed consent from adult participants. Parental or legal guardian written consent was obtained for minors, along with written assent from the minor. This study was conducted with approval of the Institutional Review Board at Boston Children’s Hospital.
: Not applicable.
: Authors, RND and CAW have filed a patent application on the MIPP-Seq protocol for the detection and validation of mosaic and germline mutations using multiple primers containing molecular barcoding and the subsequent statistical analytic process. The application does not restrict the use of MIPP-Seq in a research setting.