Received: 16 February 2021
Accepted: 25 August 2021
First Online: 27 August 2021
: All studies were performed in accordance with the Declaration of Helsinki protocols. The studies were reviewed and approved by institutional ethics boards including Bio Ethics Committee (BEC) of Quaid-i-Azam University, Islamabad, Pakistan and the institutional research ethics board of Centre for Addiction and Mental Health, Toronto, Canada. Subjects or their legal representatives participating in this study gave written informed consent to participate in this study and consented for DNA tests including exome sequencing.
: Subjects or their legal representatives participating in this study provided written consent for publication of the results.
: The authors declare that they have no competing interests.