Funding for this research was provided by:
F. Hoffmann-La Roche
Received: 10 July 2017
Accepted: 25 February 2018
First Online: 27 April 2018
Ethics approval and consent to participate
: This study was approved by the Independent Scientific Advisory Committee for Medicines and Healthcare Products Regulatory Agency research (protocol number 16_060R).
: Not applicable
: MB, DR, JS, SJ, and CRM have no conflicts of interest.SCC was an employee of Genentech at the timing of study conduction, a member of the F. Hoffmann-La Roche group.KK is an employee of F. Hoffmann-La Roche Ltd.LH reports grants from Genentech during the conduct of the study, and other payment for consultancy (F. Hoffmann-La Roche Ltd., Astra Zeneca, Novartis, Glaxo Smith Kline, Teva, Medimmune, Amgen, Boehringer Ingelheim, Aerocrine and Vitalograph), outside the submitted work.
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