Funding for this research was provided by:
Japan Agency for Medical Research and Development (16ek0109051h0003, 19gm4010002h0001, 19fk0108157h0001, 20bm0804007h0004)
Received: 27 January 2021
Accepted: 13 June 2021
First Online: 17 June 2021
: This prospective registry study included discovery and validation cohorts and was approved by the Institutional Review Board of Kyoto Universities (G1059) and other collaborative institutions.
: All study participants (patients and controls) provided written informed consent.
: TN, THanda, YM, YNakatsuka, KTanizawa, and THirai have received research grants from FUJIFILM Corporation. THanda is in the employment of the Collaborative Research Laboratory funded by Teijin Pharma Co., Ltd. RU reports personal fees from Eisai, Sawai Pharmaceutical, and CAC Croit, outside the submitted work. KTanizawa. reports grants from Japan’s Ministry of Health, Labor, and Welfare, grants from Japan Society for the Promotion of Science, grants from Japan Intractable Diseases Research Foundation, grants from Ms. Mieko Sonoda Memorial Research Fund for Interstitial Lung Diseases, personal fees from KYORIN Pharmaceutical Co., Ltd., and Nippon Boehringer Ingelheim Co., Ltd., outside the submitted work. K. Chin reports grants from the Japanese Ministry of Education, Culture, Sports, Science and Technology, grants from the Intractable Respiratory Diseases and Pulmonary Hypertension Research Group, the Ministry of Health, Labour and Welfare, Japan, grants from the Center of Innovation Program, and the Global University Project from Japan Science and Technology Agency, Japan Agency for Medical Research and Development, grants from the Research Foundation for Healthy Aging, grants from the Health, Labour and Welfare Sciences Research Grants, Research on Region Medical, during the conduct of the study; grants from Philips-Respironics, Teijin Pharma, Fukuda Denshi, Fukuda Lifetec Keiji and ResMed, outside the submitted work.