Received: 14 September 2021
Accepted: 4 January 2022
First Online: 12 January 2022
: Informed consent was obtained from all subjects. The study was approved by the Hamilton Integrated Research Ethics Board (Project #1281).
: TH reports grants and non-financial support from Fisher and Paykel healthcare, and personal fees from Sanofi, outside the submitted work, and is supported by the McMaster Department of Medicine Early Career Award. MM is supported by an early career investigator award from CIHR, Canadian Asthma Allergy and Immunology Foundation, and reports grants from CIHR, Methapharm Specialty Pharmaceuticals, and personal fees from Astra Zeneca and GlaxoSmithKline, outside the submitted work. PN reports grants and personal fees from AZ, grants from Novartis, grants and personal fees from Teva, grants from Sanofi, grants and personal fees from Roche, personal fees from Novartis, personal fees from Merck, personal fees from Equillium, grants from Foresee, outside the submitted work, and is supported by the Frederick E Hargreave Teva Innovation Chair in Airway Diseases. The other authors report no conflict of interest.